介孔二氧化硅基纳米粒作为药物载体的最新研究进展

江悦1, 尚宏周2*, 孙晓然1, 韩利华1, 杨梦然1, 来士胜3

化工新型材料 ›› 2021, Vol. 49 ›› Issue (9) : 240 -243.

PDF
化工新型材料 ›› 2021, Vol. 49 ›› Issue (9) : 240-243. DOI: 10.19817/j.cnki.issn 1006-3536.2021.09.052
开发与应用

介孔二氧化硅基纳米粒作为药物载体的最新研究进展

    江悦1, 尚宏周2*, 孙晓然1, 韩利华1, 杨梦然1, 来士胜3
作者信息 +

Recent research advance on mesoporous SiO2 nanoparticle as drug carrier

  • Jiang Yue1, Shang Hongzhou2, Sun Xiaoran1, Han Lihua1, Yang Mengran1, Lai Shisheng3
Author information +
文章历史 +
PDF

摘要

介孔SiO2纳米粒具有较大的比表面积、均匀可控的粒径、良好的生物相容性和生物降解性,被广泛用于药物载体。通过对介孔SiO2纳米粒进行刺激响应性修饰作为药物载体方面的研究进行了归纳总结,并对其未来发展趋势进行了展望。

Abstract

Mesoporous silica(SiO2) nanoparticles are widely used as drug carriers because of their large specific surface area,uniform and controllable particle size,good biocompatibility and biodegradability.The research on stimulation response modification of mesoporous SiO2 nanoparticles as drug carriers was summarized,and looked forward to its future development trend.

关键词

介孔二氧化硅 / 表面修饰 / 刺激响应性 / 药物载体

Key words

mesoporous silica / surface modification / stimuli response / drug carrier

引用本文

引用格式 ▾
介孔二氧化硅基纳米粒作为药物载体的最新研究进展[J]. 化工新型材料, 2021, 49(9): 240-243 DOI:10.19817/j.cnki.issn 1006-3536.2021.09.052

登录浏览全文

4963

注册一个新账户 忘记密码

参考文献

[1] Gao Y,Zhong S,Xu L,et al.Mesoporous silica nanoparticles capped with graphene quantum dots as multifunctional drug carriers for photo-thermal and redox-responsive release[J].Microporous and Mesoporous Materials,2019,278:130-137.
[2] Yu F,Wu H,Tang Y,et al.Temperature-sensitive copolymer-coated fluorescent mesoporous silica nanoparticles as a reactive oxygen species activated drug delivery system[J].International Journal of Pharmaceutics,2018,536(1):11-20.
[3] Sodagar Taleghani A,Ebrahimnejad P,Heidarinasab A,et al.Sugar-conjugated dendritic mesoporous silica nanoparticles as pH-responsive nanocarriers for tumor targeting and controlled release of deferasirox[J].Materials Science and Engineering:C,2019,98:358-368.
[4] Asgari M,Soleymani M,Miri T,et al.A robust method for fabrication of monodisperse magnetic mesoporous silica nanoparticles with core-shell structure as anticancer drug carriers[J].Journal of Molecular Liquids,2019,292:111367.
[5] Luo W,Xu X,Zhou B,et al.Formation of enzymatic/redox-switching nanogates on mesoporous silica nanoparticles for anticancer drug delivery[J].Materials Science and Engineering:C,2019,100:855-861.
[6] Zhang J,Shen B,Chen L,et al.A dual-sensitive mesoporous silica nanoparticle based drug carrier for cancer synergetic therapy[J].Colloids and Surfaces B:Biointerfaces,2019,175:65-72.
[7] Mai Z,Chen J,Hu Y,et al.Novel functional mesoporous silica nanoparticles loaded with Vitamin E acetate as smart platforms for pH responsive delivery with high bioactivity[J].Journal of Colloid and Interface Science,2017,508:184-195.
[8] Peralta M E,Jadhav S A,Magnacca G,et al.Synthesis and in vitro testing of thermoresponsive polymer-grafted core-shell magnetic mesoporous silica nanoparticles for efficient controlled and targeted drug delivery[J].Journal of Colloid and Interface Science,2019,544:198-205.
[9] Murugan B,Krishnan U M.Chemoresponsive smart mesoporous silica systems-an emerging paradigm for cancer therapy[J].International Journal of Pharmaceutics,2018,553(1/2):310-326.
[10] Li T,Shi S,Goel S,et al.Recent advancements in mesoporous silica nanoparticles towards therapeutic applications for cancer[J].Acta Biomaterialia,2019,89:1-13.
[11] Moreira A F,Dias D R,Correia I J.Stimuli-responsive mesoporous silica nanoparticles for cancer therapy:a review[J].Microporous and Mesoporous Materials,2016,236:141-157.
[12] Jafari S,Derakhshankhah H,Alaei L,et al.Mesoporous silica nanoparticles for therapeutic/diagnostic applications[J].Biomedicine & Pharmacotherapy,2019,109:1100-1111.
[13] Lin J T,Liu Z K,Zhu Q L,et al.Redox-responsive nanocarriers for drug and gene co-delivery based on chitosan derivatives modified mesoporous silica nanoparticles[J].Colloids and Surfaces B:Biointerfaces,2017,155:41-50.
[14] Venkatesan P,Thirumalivasan N,Yu H P,et al.Redox stimuli delivery vehicle based on transferrin-capped MSNPs for targeted drug delivery in cancer therapy[J].ACS Applied Bio Materials,2019,2(4):1623-1633.
[15] Yuan X,Peng S,Lin W,et al.Multistage pH-responsive mesoporous silica nanohybrids with charge reversal and intracellular release for efficient anticancer drug delivery[J].Journal of Colloid and Interface Science,2019,555:82-93.
[16] 马博乐,陈雨晴,祝星宇,等.介孔二氧化硅纳米粒的功能化修饰及其在药物研究中的应用[J].中国药房,2018,29(15):2156-2160.
[17] Li S,Dai W,Yin Z Z,et al.Synthesis of oxidized pullulan coated mesoporous silica for pH-sensitive drug delivery[J].European Polymer Journal,2020,122:109399.
[18] Beñová E,Bergé-Lefranc D,Zeleñák V,et al.Adsorption properties,the pH-sensitive release of 5-fluorouracil and cytotoxicity studies of mesoporous silica drug delivery matrix[J].Applied Surface Science,2020,504:144028.
[19] Kumar P,Tambe P,Paknikar K M,et al.Mesoporous silica nanoparticles as cutting-edge theranostics:advancement from merely a carrier to tailor-made smart delivery platform[J].Journal of Controlled Release,2018,287:35-57.
[20] Sábio R M,Meneguin A B,Ribeiro T C,et al.New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery[J].International Journal of Pharmaceutics,2019,564:379-409.
[21] Hu C,Huang P,Zheng Z,et al.A facile strategy to prepare an enzyme-responsive mussel mimetic coating for drug delivery based on mesoporous silica nanoparticles[J].Langmuir,2017,33(22):5511-5518.
[22] Zhang Y,Xu J.Mesoporous silica nanoparticle-based intelligent drug delivery system for bienzyme-responsive tumour targeting and controlled release[J].Royal Society Open Science,2018,5(1):170986.
[23] Hoang Thi T T,Cao V D,Nguyen T N Q,et al.Functionalized mesoporous silica nanoparticles and biomedical applications[J].Materials Science and Engineering:C,2019,99:631-656.
[24] Liu Z,Shi J,Wang Y,et al.Facile preparation of pyrenemethyl ester-based nanovalve on mesoporous silica coated upconversion nanoparticle for NIR light-triggered drug release with potential monitoring capability[J].Colloids and Surfaces A:Physicochemical and Engineering Aspects,2019,568:436-444.
[25] Le Thi T N,Nguyen T H,Hoang D Q,et al.Development of new magnetic nanoparticles:oligochitosan obtained by γ-rays and-coated Fe3O4 nanoparticles[J].Applied Surface Science,2017,422:863-868.
[26] Sanchez-Salcedo S,Vallet-Regí M,Shahin S A,et al.Mesoporous core-shell silica nanoparticles with anti-fouling properties for ovarian cancer therapy[J].Chemical Engineering Journal,2018,340:114-124.
[27] Guisasola E,Asín L,Beola L,et al.Beyond traditional hyperthermia:in vivo cancer treatment with magnetic-responsive mesoporous silica nanocarriers[J].ACS Applied Materials & Interfaces,2018,10(15):12518-12525.
[28] Wu Y,Xu Z,Sun W,et al.Co-responsive smart cyclodextrin-gated mesoporous silica nanoparticles with ligand-receptor engagement for anti-cancer treatment[J].Materials Science and Engineering:C,2019,103:109831.
[29] Chen C,Yao W,Sun W,et al.A self-targeting and controllable drug delivery system constituting mesoporous silica nanoparticles fabricated with a multi-stimuli responsive chitosan-based thin film layer[J].International Journal of Biological Macromolecules,2019,122:1090-1099.

基金资助

河北省教育厅项目(JYG2019003)

AI Summary AI Mindmap
PDF

342

访问

0

被引

导航
相关文章

AI思维导图

/